AURKC —— 极光激酶C

AURKC

极光激酶C

aurora kinase C

该基因编码丝氨酸/苏氨酸蛋白激酶的极光亚家族的成员。编码的蛋白是一种与Aurora-B和内部着丝粒蛋白形成复合物的染色体过客蛋白，在有丝分裂过程中可能在组织与中心体/纺锤体功能有关的微管中发挥作用。该基因在几种癌细胞系中过表达，表明参与致癌信号转导。选择性剪接导致多个转录物变体。[由RefSeq提供，2008年7月]

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]