EGFR —— 表皮生长因子受体

EGFR

表皮生长因子受体

epidermal growth factor receptor

该基因编码的蛋白是跨膜糖蛋白，它是蛋白激酶超家族的成员。该蛋白是表皮生长因子家族成员的受体。EGFR是与表皮生长因子结合的细胞表面蛋白。蛋白质与配体的结合诱导受体二聚化和酪氨酸自磷酸化并导致细胞增殖。该基因的突变与肺癌有关。[由RefSeq提供，2016年6月]

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]