IFNG —— 干扰素γ

IFNG

干扰素γ

interferon gamma

该基因编码可溶性细胞因子，该细胞因子是II型干扰素类别的成员。先天和适应性免疫系统的细胞都会分泌编码的蛋白质。活性蛋白是与干扰素γ受体结合的同型二聚体，它会触发细胞对病毒和微生物感染的反应。该基因的突变与对病毒，细菌和寄生虫感染以及几种自身免疫性疾病的敏感性增加有关。[由RefSeq提供，2015年12月]

This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]