PARP1 —— 聚（ADP-核糖）聚合酶1

PARP1

聚（ADP-核糖）聚合酶1

poly(ADP-ribose) polymerase 1

该基因编码染色质相关的酶，聚（ADP-核糖基）转移酶，该酶通过聚（ADP-核糖基）化修饰各种核蛋白。修饰依赖于DNA，并且涉及各种重要细胞过程的调控，例如分化，增殖和肿瘤转化，还涉及涉及从DNA损伤中恢复细胞的分子事件的调控。此外，该酶可能是范可尼贫血中的突变位点，并可能参与I型糖尿病的病理生理。[由RefSeq提供，2008年7月]

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]