医疗特长：（1）在骨肉瘤、尤文肉瘤、滑膜肉瘤等骨与软组织恶性肿瘤保肢手术及综合治疗方面具有丰富经验，擅长四肢恶性骨与软组织肿瘤保肢手术，个体化假体设计及生物重建，儿童骨肿瘤可延长假体保肢手术及儿童半关节假体手术。（2）骨盆和脊柱肿瘤的精准切除、3D打印假体重建。脊柱肿瘤的机器人手术及综合治疗等。（3）复杂的骨与软组织恶性肿瘤的综合诊断。颈、胸椎等高危部位的骨穿刺活检。骨与软组织恶性肿瘤的化疗、靶向、免疫治疗。（4）嗜酸性肉芽肿的综合治疗。研究方向：肢体骨与软组织恶性肿瘤保肢手术，骨盆和脊柱肿瘤的切除与重建。围绕整合肿瘤学观念进行骨与软组织恶性肿瘤的个体化、精准综合诊治研究。主要教育和工作经历：1994.08－1999.08 中山大学外科学骨科专业硕士博士研究生1999.08-2002.12 中山大学附属第一医院骨科主治医生，讲师2001.08-2002.10 香港大学玛丽医院骨科学系访问学者，AO Fellow2002.12-2015.12 中山大学附属第一医院骨科副主任医师2005-至今 中山大学附属第一医院骨肿瘤科副主任2015.12-至今 中山大学附属第一医院骨肿瘤科主任医师社会兼职：中华医学会骨科学分会骨肿瘤学组 委员中国抗癌协会肉瘤专业委员会骨转移瘤学组副组长、软组织肉瘤学组副组长、四肢学组副组长、骨肿瘤和骨转移瘤专业委员会修复重建学组副组长中国骨科医师协会骨肿瘤学组 委员中国医药教育协会骨与软组织肿瘤专业委员会委员、肢体肿瘤分会 委员广东省基层医药学会骨科修复重建专业委员会 副主任委员广东省医学会肿瘤学分会骨软组织肿瘤学组 组长广东省医学会骨科学分会第八届委员会骨肿瘤学组 副组长科研情况：主持国家及省部级科研项目多余项；发表SCI收录文章20余篇，其中第一/通讯发表7篇，单篇最高影响因子11.21。(1) Hong-Bo Li#,Gang Huang#（黄纲，第一作者）,Jian Tu#,Dong-Ming Lv, Qing-Lin Jin,Jun-Kai Chen,Yu-Tong Zou,Dung-Fang Lee,Jing-Nan Shen*,Xian-Biao Xie*. METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma. EBioMedicine.2022 Aug;82:104142.(2) Hong-Bo Li#,Jun-Kai Chen#,Ze-XinSu#,Qing-Lin Jin, Li-Wen Deng, Gang Huang*（黄纲，通讯作者）, Jing-Nan Shen*.Cordycepin augments the chemosensitivity of osteosarcoma to cisplatin by activating AMPK and suppressing the AKT signaling pathway. Cancer Cell International. 2021 Dec 25;21(1):706.(3) href="https://pubmed.ncbi.nlm.nih.gov/?term=Li+H&cauthor_id=32863940">Hongyi Li#, href="https://pubmed.ncbi.nlm.nih.gov/?term=Tu+J&cauthor_id=32863940">Jian Tu#, href="https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+Z&cauthor_id=32863940">Zhiqiang Zhao#, href="https://pubmed.ncbi.nlm.nih.gov/?term=Chen+L&cauthor_id=32863940">Lijuan Chen, href="https://pubmed.ncbi.nlm.nih.gov/?term=Qu+Y&cauthor_id=32863940">Yueting Qu, href="https://pubmed.ncbi.nlm.nih.gov/?term=Li+H&cauthor_id=32863940">Hongbo Li, href="https://pubmed.ncbi.nlm.nih.gov/?term=Yao+H&cauthor_id=32863940">Hao Yao, href="https://pubmed.ncbi.nlm.nih.gov/?term=Wang+X&cauthor_id=32863940">Xiaoshuai Wang, href="https://pubmed.ncbi.nlm.nih.gov/?term=Lee+DF&cauthor_id=32863940">Dung-Fang Lee, href="https://pubmed.ncbi.nlm.nih.gov/?term=Shen+J&cauthor_id=32863940">Jingnan Shen, href="https://pubmed.ncbi.nlm.nih.gov/?term=Wen+L&cauthor_id=32863940">Lili Wen, href="https://pubmed.ncbi.nlm.nih.gov/?term=Huang+G&cauthor_id=32863940">Gang Huang*（黄纲，通讯作者）, href="https://pubmed.ncbi.nlm.nih.gov/?term=Xie+X&cauthor_id=32863940">Xianbiao Xie*.Molecular signatures of BRCAness analysis identifies PARP inhibitor Niraparib as a novel targeted therapeutic strategy for soft tissue Sarcomas. Theranostics. 2020 Jul 25;10(21):9477-9494.（4） href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Li%20H%5BAuthor%5D&cauthor=true&cauthor_uid=30237968">Li H#, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Xie%20X%5BAuthor%5D&cauthor=true&cauthor_uid=30237968">Xie X#, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Yin%20J%5BAuthor%5D&cauthor=true&cauthor_uid=30237968">Yin J, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Tu%20J%5BAuthor%5D&cauthor=true&cauthor_uid=30237968">Tu J, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Wang%20X%5BAuthor%5D&cauthor=true&cauthor_uid=30237968">Wang X, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Liu%20W%5BAuthor%5D&cauthor=true&cauthor_uid=30237968">Liu W, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Zhang%20J%5BAuthor%5D&cauthor=true&cauthor_uid=30237968">Zhang J, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Li%20H%5BAuthor%5D&cauthor=true&cauthor_uid=30237968">Li H, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Zou%20C%5BAuthor%5D&cauthor=true&cauthor_uid=30237968">Zou C, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Wang%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=30237968">Wang Y, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Shen%20J%5BAuthor%5D&cauthor=true&cauthor_uid=30237968">Shen J, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Huang%20G%5BAuthor%5D&cauthor=true&cauthor_uid=30237968">Huang G*（黄纲，通讯作者）. Comparison between low-dose chemotherapy and surgery for the treatment of extremity-associated solitary bone lesions in children with Langerhans cell histiocytosis in South China: A case-control study. Journal of Bone Oncology ； 2018 Feb 15;12:1-6.（5） href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Liao%20H%5BAuthor%5D&cauthor=true&cauthor_uid=30410352">Liao H#, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Xie%20X%5BAuthor%5D&cauthor=true&cauthor_uid=30410352">Xie X, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Xu%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=30410352">Xu Y, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Huang%20G%5BAuthor%5D&cauthor=true&cauthor_uid=30410352">Huang G（黄纲，通讯作者）. Identification of driver genes associated with chemotherapy resistance of Ewing’s sarcoma. href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Identification+of+driver+genes+associated+with+chemotherapy+resistance+of+Ewing%E2%80%99s+sarcoma" title="OncoTargets and therapy.">Onco Targets Ther.2018 Oct 15;11:6947-6956.其他主要工作成绩（比如获奖情况等）：①恶性骨肿瘤的三结合诊断，保肢治疗和基础研究，教育部一等奖,（参与）②恶性骨肿瘤的三结合诊断，保肢治疗和基础研究，广东省科学技术奖励二等奖（参与） ③骨肉瘤特异性抗原的蛋白组学研究及其诊治应用, 广州市科学技术奖励三等奖（参与）④骨肉瘤精准诊疗技术创新及推广应用，广东省精准医学科技奖一等奖（参与）