医疗/科研特长：主要以斑马鱼为模式动物研究人类重要疾病相关基因的功能。以第一/通讯（共同第一/通讯）作者发表SCI论文10多篇，其中2篇论文获得Faculty of 1000推荐。研究方向：人类疾病相关易感基因的致病机制研究主要教育和工作经历：2000年12月获博士学位。2001年到2011年期间，先后在新加坡分子和细胞生物学研究院（IMCB）从事博士后研究和担任研究员、资深研究员工作，主要以模式生物拟南芥、斑马鱼为研究对象，研究机体器官发育的分子机理。2011年12月，作为中山大学“百人计划”引进人才到本院工作，建立了斑马鱼疾病模式动物公共平台，开展人类疾病相关易感基因的致病机制研究。社会兼职：广东省精准医学应用学会疾病模型分会第一届委员会副主任委员。中国实验动物学会水生实验动物专业委员会委员。论著：href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Wang%20J%5BAuthor%5D&cauthor=true&cauthor_uid=32007595"Wang J, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Guo%20X%5BAuthor%5D&cauthor=true&cauthor_uid=32007595">Guo X, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Wang%20D%5BAuthor%5D&cauthor=true&cauthor_uid=32007595"Wang D, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Yang%20S%5BAuthor%5D&cauthor=true&cauthor_uid=32007595"Yang S*, Expression patterns of pcbp gene family members during zebrafish embryogenesis. Gene Expr Patterns. 2020 Jan 31; 35:119097. doi: 10.1016/j.gep.2020.119097. [Epub ahead of print]Zhang M, Wei Y, Liu Y, Guan W, Zhang X, Kong J, Li H, Yang S*, Wang H*, Metastatic Phosphatase PRL-3 induces Ovarian Cancer Stem Cell Subpopulation through Phosphatase-independent Deacetylation Modulations. iScience 2020 Jan 24;23(1):100766. doi: 10.1016/j.isci.2019.100766.Shi H, Li H, Yuan R, Guan W, Zhang X, Zhang S, Zhang W, Tong F, Li L, Song Z, Wang C, Yang S*., Wang H*.. PCBP1 depletion promotes tumorigenesis through attenuation of p27 Kip1 mRNA stability and translation. Journal of Experimental & Clinical Cancer Research, 2018, 37：187. ePub，doi: 10.1186/s13046-018-0840-1.Xu L, Zhang M, Li H, Guan W, Liu B, Liu F, Wang H, Li Juan, Yang S, Tong X*，Wang H*. SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia. href="https://www.ncbi.nlm.nih.gov/pubmed/?term=SH3BGRL+as+a+novel+prognostic+biomarker+is+down-regulated+in+acute" title="Leukemia & lymphoma.">Leuk Lymphoma. 2018, 59(4):918-930. href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Gao%20W%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Gao W, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Chen%20C%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Chen C, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Zhou%20T%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Zhou T, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Yang%20S%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Yang S, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Gao%20B%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Gao B, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Zhou%20H%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Zhou H, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Lian%20C%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Lian C, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Wu%20Z%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Wu Z, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Qiu%20X%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Qiu X, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Yang%20X%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Yang X, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Alattar%20E%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Alattar E, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Liu%20W%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Liu W, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Su%20D%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Su D, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Sun%20S%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Sun S, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Chen%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Chen Y, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Cheung%20KMC%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Cheung KMC, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Song%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Song Y, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Luk%20KKD%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Luk KKD, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Chan%20D%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Chan D, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Sham%20PC%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Sham PC, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Xing%20C%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Xing C, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Khor%20CC%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Khor CC, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Liu%20G%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Liu G, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Yang%20J%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Yang J, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Deng%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Deng Y, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Hao%20D%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Hao D, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Huang%20D%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Huang D, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Li%20QZ%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Li QZ, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Xu%20C%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Xu C*, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Su%20P%5BAuthor%5D&cauthor=true&cauthor_uid=28714182">Su P*. Rare coding variants in MAPK7 predispose to adolescent idiopathic scoliosis. href="https://www.ncbi.nlm.nih.gov/pubmed/28714182" title="Human mutation.">Human Mutation. 2017, 38(11):1500-1510Li L, Shi H, Zhang M, Guo X, Tong F, Zhang W, Zhou J, Wang H*, Yang S*. Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish. International Journal of Oncology, 2016, 48(4):1541-1552. Tong F, Zhang M, Guo X, Shi H, Guan W, Wang H* and Yang S*. Expression patterns of SH3BGR family members in zebrafish development. Development Genes and Evolution 2016, 226(4): 287-295. Zhang W, Shi H, Zhang M, Liu B, Mao S, Li L, Tong F, Liu G, Yang S*, Wang H*. Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation. International Journal of Biochemistry and Cell Biology. 2016, 73: 127-136. Qu href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Qu%20S%5BAuthor%5D&cauthor=true&cauthor_uid=24737397">S, Liu B, Guo href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Guo%20X%5BAuthor%5D&cauthor=true&cauthor_uid=24737397">X, Shi href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Shi%20H%5BAuthor%5D&cauthor=true&cauthor_uid=24737397">H, Zhou href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Zhou%20M%5BAuthor%5D&cauthor=true&cauthor_uid=24737397">M, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Li%20L%5BAuthor%5D&cauthor=true&cauthor_uid=24737397">Li L, Yang href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Yang%20S%5BAuthor%5D&cauthor=true&cauthor_uid=24737397">S, Tong href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Tong%20X%5BAuthor%5D&cauthor=true&cauthor_uid=24737397">X*, Wang href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Wang%20H%5BAuthor%5D&cauthor=true&cauthor_uid=24737397">H*. Independent oncogenic and therapeutic significance of phosphatase PRL-3 in FLT3-ITD–negative acute myeloid leukemia href="https://www.ncbi.nlm.nih.gov/pubmed/24737397" title="Cancer.">Cancer. 2014, 120(14): 2130-2141.Yang S #, Aw SS, Chang Q, Korzh S, Korzh V*, and Peng J*. Depletion of Bhmt elevates sonic hedgehog transcript levels to promote pancreatic islet development in zebrafish, Endocrinology, 2011: 152(12):4706-4717.Korzh S, Winata CL, Zheng W, Yang S, Yin A, Ingham P, Gong Z*. The interaction of epithelial Ihha and mesenchymal Fgf10 in zebrafish esophageal and swimbladder development. Developmental Biology, 2011,359：262–276.Ma H, Zhang S, Ji L, Zhu H, Yang S, Fang X*, Yang R*. Mapping and in silico isolation of the EUI1 gene controlling upper internode elongation in rice. Plant Molecular Biology, 2006, 60: 87-94。Yang S #, Puah CS, Xie L, Jiang L, Zhang X, Chen L, Ye D*. Over-expression of TPD1 alters the cell fates in the arabidopsis carpel and tapetum via genetic Interaction with EMS1/EXS. Plant Physiology, 2005, 139: 186-191.Jiang L, Yang S, Xie L, Puah CS, Yang W, Sundaresan V, Ye D*. VANGUARD1 encodes a pectin methylesterase that enhances pollen tube growth in the Arabidopsis style and transmitting tract. Plant Cell, 2005, 17: 584-596. (Faculty of 1000 推荐).Yang S #, Xie L, Mao H, Puah CS, Yang W, Jiang L, Ye D*. 2003. Tapetum determinant 1 gene is required for cell specialization in the Arabidopsis anther. Plant Cell, 15: 2792-2804. (Faculty of 1000推荐).