一、研究方向：1、胰腺恶性肿瘤、神经内分泌肿瘤的临床与基础研究； 2、胆道恶性肿瘤临床与基础研究；3、肝脏恶性肿瘤临床与基础研究；至今已主持5项国家自然科学基金、近10项省部级基金资助的课题研究，取得了丰硕的成果。二、主要教育和工作经历：1986.09～1992.06 中山医科大学 临床医学（本科）1992.07～1997.12 中山医科大学附属第一医院外科住院医师1996.09～1999.06 中山医科大学 外科学（博士）1997.12～2000.12 中山医科大学附属第一医院肝胆外科讲师、主治1999.01～2000.01 香港中文大学威尔斯亲王医院外科访问学者2000.12～2003.12 中山大学附属第一医院肝胆外科副主任医师2003.12～2006.02 美国University of Pittsburgh肿瘤外科博士后2006.02～2006.12 中山大学附属第一医院肝胆外科副主任医师2006.12～至今中山大学附属第一医院肝胆外科教授、主任医师（2007.08始 聘为博士生导师）三、社会兼职：1、中华医学会外科学分会第十八届委员会胰腺外科学组委员；2、中国抗癌协会神经内分泌肿瘤专业委员会副主任委员；3、中国抗癌协会胆道肿瘤专业委员会第四届委员会常委；4、中国医师协会胰腺病学专业委员会第二届委员会常务委员；5、中国医师协会外科医师分会胆道外科医师委员会第二届委员会常务委员兼副秘书；6、中国医师协会机器人外科医师分会委员7、中国研究型医院学会数字医学临床外科专业委员会副主任委员、肝门部胆管癌学组组长；8、中国研究型医院学会术后快速康复专业委员会常委；9、中国研究型医院学会智能医学专业委员会常委；10、国际肝胆胰协会中国分会胆道肿瘤专业委员会副主任委员11、广东省医学会外科学分会副主任委员12、广东省医学会肝胆胰外科学分会常务委员；13、广东省医师协会胰腺病学专业委员会副主任委员；14、广东省医疗行业协会肝胆胰外科管理分会主任委员；15、广东省临床医学学会肝胆胰外科专业委员会主任委员；16、广东省抗癌协会胰腺癌专业委员会副主任委员；17、广东省抗癌协会胆道肿瘤专业委员会主任委员；18、Gastroenterology Report》、《中华肝胆外科杂志》、《中华消化外科杂志》、《中华胰腺病学杂志》、《中华普通外科文献杂志》电子版等多家杂志编委。四、发表论文：目前已在“Advanced Science (IF=17.521)”、“ACS Nano (IF=18.027)” 、 “Cancer Communications (IF=15.283)”、“J Exp Clin Cancer Res (IF=12.658)”、“Cancer Letters (IF=9.756)”、“Oncogene (IF=8.756)”、“Int J Biol Sci (IF=10.750)”、“Clin Trans Med (IF=8.554)”、 “Applied Materials Today (IF=8.663)”、“Nanoscale (IF=8.307)”、“Cancer (IF=6.921)”、“Br J Surg (IF=11.122)”、 “Cancer Science (IF=6.518)”、“Ann Surg Oncol (IF=4.339)”、”HPB (Oxford) (IF=3.842)”、”Pancreas (IF=3.242)”等SCI杂志、及“中华外科杂志”、”中华消化外科杂志”、“中华肝胆外科杂志”、“中国实用外科杂志”等国内核心期刊发表第一作者和（或）通讯作者论文120多篇。近期发表的部分论文如下：Shi YH, Xu QC, Zhu YQ, Liu ZD, Zhao GY, Liu Q, Wang XY, Wang JQ, Xu X, Su Q, Lai JM, Huang CS, Yin XY. Imatinib facilitates gemcitabine sensitivity by targeting epigenetically activated PDGFC signaling in pancreatic cancer. Mol Ther. 2022 Nov 15:S1525-0016(22)00662-1.（通讯作者）Huang CS, Xu QC, Dai C, Wang L, Tien YC, Li F, Su Q, Huang XT, Wu J, Zhao W, Yin XY. Nanomaterial-Facilitated Cyclin-Dependent Kinase 7 Inhibition Suppresses Gallbladder Cancer Progression via Targeting Transcriptional Addiction. ACS Nano. 2021 Sep 28;15(9):14744-14755.（通讯作者）Xu QC, Tien YC, Shi YH, Chen S, Zhu YQ, Huang XT, Huang CS, Zhao W, Yin XY. METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m6A-YTHDF2-dependent manner. Oncogene. 2022 Mar;41(11):1622-1633.（通讯作者）Huang XT, Li JH, Zhu XX, Huang CS, Gao ZX, Xu QC, Zhao W, Yin XY. HNRNPC impedes m6A-dependent anti-metastatic alternative splicing events in pancreatic ductal adenocarcinoma. Cancer Lett. 2021 Oct 10;518:196-206.（通讯作者）Li YX, Zhu XX, Wu X, Li JH, Ni XH, Li SJ, Zhao W, Yin XY. ACLP promotes activation of cancer-associated fibroblasts and tumor metastasis via ACLP-PPARγ-ACLP feedback loop in pancreatic cancer. Cancer Lett. 2022 Sep 28;544:215802.（通讯作者）Qiong-Cong Xu, Yi-Chih Tien, Yin-Hao Shi, Siyun Chen, Ying-Qin Zhu, Xi-Tai Huang, Chen-Song Huang, and Wei Zhao, Xiao-Yu Yin. METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m6A-YTHDF2-dependent manner. Oncogene 2022; doi:10.1038/s41388-022-02185-1.（通讯作者）Chen-Song Huang, Ying-Qin Zhu, Qiong-Cong Xu, Siyun Chen, Yue Huang, Guangyin Zhao, Xuhao Ni, Bao Liu, Wei Zhao, Xiao-Yu Yin.YTHDF2 promotes intrahepatic cholangiocarcinoma progression and desensitizes cisplatin treatment by increasing CDKN1B mRNA degradation Running title YTHDF2 drives ICC progression and chemo-resistance. Clin. Transl. Med. 2022;12:e848.（通讯作者）Ya-Xiong Li, Xiao-Xu Zhu, Xiao Wu, Jian-Hui Li, Xu-Hao Ni, Shi-Jin Li, Wei Zhao, Xiao-Yu Yin. ACLP promotes activation of cancer-associated fibroblasts and tumor metastasis via ACLP-PPARγ-ACLP feedback loop in pancreatic cancer. Cancer Letter 2022. https://doi.org/10.1016/j.canlet.2022.215802.（通讯作者）Ni X; Wu X; Zhu XX; Li JH; Yin XY; Lu L. Carabin Deficiency Aggravates Hepatic Ischemia-Reperfusion Injury Through Promoting Neutrophil Trafficking via Ras and Calcineurin Signaling. Front Immunol.2022;13;773291.（共同通讯作者）Huang CS, Xu QC, Dai CL, Wang LY, Tien YC, Li FX, Su Q, Huang XT, Wu J, Zhao W, Yin XY. Nanomaterial-Facilitated Cyclin-Dependent Kinase7 Inhibition Suppresses Gallbladder Cancer Progression via Targeting Transcriptional Addiction. ACS Nano. 2021;15(9):14744-14755. （通讯作者）Huang Xi-Tai, Cai Jian-Peng, Chen Wei, Huang Chen-Song, Li Jian-Hui. Gang Tian-Tian, Liang Li-Jian, Yin Xiao-Yu. Establishment and validation of a nomogram for predicting overall survival of node negative perihilar cholangiocarcinoma. Asian J Surg. 2022;45:712-717. （通讯作者）Jian-Peng Cai, Wei Chen, Liu-Hua Chen, Xi-Yu Wang, Jia-Ming Lai, Xiao-Yu Yin. Comparison between robotic-assisted and laparoscopic left hemi-hepatectomy. Asian J Surg 2022;45(1):265-268. （通讯作者）Xi-Tai Huang, Jian-Hui Li, Xiao-Xu Zhu, Chen-Song Huang, Zhuo-Xing Gao, Qiong-Cong Xu, Wei Zhao, Xiao-Yu Yin. HNRNPC impedes m6 A-dependent anti-metastatic alternative splicing events in pancreatic ductal adenocarcinoma. Cancer Letter. 2021;518:196–206. （通讯作者） name="_Hlk32999545">Qiong-Cong Xu, name="_Hlk44334512">Liying Wang, name="_Hlk34742961"> name="_Hlk44334517">Tong Tong, name="_Hlk44334522">Xi-Tai Huang, name="_Hlk44334527">Chen-Song Huang, name="_Hlk34743007">Fuxi Li, name="_Hlk44334536">Qiao Su, Yi-Chih Tien, name="_Hlk44334550">Jun Wu, name="_Hlk44334554">Wei Zhao, name="_Hlk44334559">Xiao-Yu Yin. Efficient Delivery of BRD4 Inhibitor by Glutathione-sensitive Nanoparticle to Suppress Gallbladder Cancer Through Inhibiting NF-κB Signaling name="_Hlk43807480">. Applied Material Today 2020;21:100849. （通讯作者）Xi-Yu Wang, Jian-Peng Cai, Le-Le Song, Chen-Song Huang, Wei Chen, Xi-Tai Huang, Shi-Fu Chen, Xin-Yi Liu, Xiao-Yu Yin. Identification of Genomic Alterations in Sporadic Pancreatic Neurogenic Tumors. Pancreas 2020;49:1393-1397. （通讯作者）Xi-Tai Huang, Chen-Song Huang, Chen Liu, Wei Chen, Jian-Peng Cai, He Cheng, Xing-Xing Jiang, Li-Jian Liang, Xian-Jun Yu, Xiao-Yu Yin. Development and Validation of a New Nomogram for Predicting Clinically Relevant Postoperative Pancreatic Fistula After Pancreatoduodenectomy. World J Surg 2021, 45, 261-269. （通讯作者）Xi-Tai Huang, Chen-Song Huang, Jian-Hui Li, Wei Chen, Tian-Tian Gan, Xi-Yu Wang, Li-Jian Liang, Xiao-Yu Yin. Evaluating the adequacy of nodal status in node-negative gallbladder cancer with T1b-T2 stages: use of nodal staging score. HPB (Oxford) 2021;23(5):795-801.（通讯作者）Huang CS, You X, Dai C, Xu QC, Li F, Wang L, Huang XT, Wang JQ, Li SJ, Gao Z, Wu J, Yin XY, Zhao W. Targeting Super-Enhancers via Nanoparticle-Facilitated BRD4 and CDK7 Inhibitors Synergistically Suppresses Pancreatic Ductal Adenocarcinoma. Adv. Sci. 2020, 7(7):1902926.（共同通讯作者）Chen HD, Huang CS, Xu QC, Li FX, Huang XT, Wang JQ, Li SJ, Zhao W, Yin XY. Therapeutic Targeting of CDK7 Suppresses Tumor Progression in Intrahepatic Cholangiocarcinoma. Int J Biol Sci. 2020;16(7):1207-1217.（通讯作者）Jie-Qin Wang,Li-Ying Wang,Shi-Jin Li,Tong Tong,Li Wang,Chen-Song Huang,Qiong-Cong Xu,Xi-Tai Huang,Jian-Hui Li,Jun Wu,Wei Zhao,Xiao-Yu Yin. Histone methyltransferase G9a inhibitor-loaded redox-responsive nanoparticles for pancreatic ductal adenocarcinoma therapy. Nanoscale. 2020;12(29):15767-15774.（通讯作者）Huang XT, Huang CS, Li JH, Xu QC, Yin XY. Use of nodal staging score in evaluating the accuracy of pathologic nodal status in node-negative ampullary carcinoma. J Gastrointestinal Surg. 2021;25:1001-1009.（通讯作者）Li JH, Zhu XX, Li FX, Huang CS, Huang XT, Wang JQ, Gao ZX, Li SJ, Xu QC, Zhao W, Yin XY. MFAP5 facilitates the aggressiveness of intrahepatic Cholangiocarcinoma by activating the Notch1 signaling pathway. J Exp Clin Cancer Res. 2019;38(1):476.（通讯作者）Zhu XX, Li JH, Cai JP, Hou X, Huang CS, Huang XT, Wang JQ, Li SJ, Xu QC, Yin XY. EYA4 inhibits hepatocellular carcinoma by repressing MYCBP by dephosphorylating β-catenin at Ser552. Cancer Sci. 2019;110(10):3110-3121.（通讯作者） Huang XT, Huang CS, Chen W, Cai JP, Gan TT, Zhao Y, Liu Q, Liang LJ, Yin XY. Development and validation of a nomogram for predicting overall survival of node-negative ampullary carcinoma. J Surg Oncol. 2020;121(1):518–523.（通讯作者）Gao SW, Huang CS, Huang XT, Chen LH, Chen W, Cai JP, Yin XY. Ki-67 Index of 5% is Better Than 2% in Stratifying G1 and G2 of WHO Grading System in Pancreatic Neuroendocrine Tumors. Pancreas 2019; 48(6):795-798. （通讯作者）Huang XT, Chen LH, Huang CS, Li JH, Cai JP, Chen W, Yin XY. Establishment of a Nomogram by Integrating Molecular Markers and Tumor-Node-Metastasis Staging System for Predicting the Prognosis of Hepatocellular Carcinoma. Dig Surg. 2019;36(5):426-432.（通讯作者）Huang XT, Huang CS, Li JH, Cai JP, Chen W, Yin XY. Prognostic significance of neutrophil/prealbumin ratio for intrahepatic cholangiocarcinoma undergoing curative resection. HPB (Oxford) 2018;20(12):1215-1222. （通讯作者）Huang CS, Chu J, Zhu XX, Li JH, Huang XT, Cai JP, Zhao W, Yin XY. The C/EBPβ-LINC01133 axis promotes cell proliferation in pancreatic ductal adenocarcinoma through upregulation of CCNG1. Cancer Letters 2018; 421(5):63-72. （通讯作者）Mo SJ, Hou X, Hao XY, Cai JP, Liu X, Chen W, Chen D, Yin XY. EYA4 inhibits hepatocellular carcinoma growth and invasion by suppressing NF-κB-dependent RAP1 transactivation. Cancer Communications. 2018; 38:9. （通讯作者）殷晓煜.机器人辅助肝门部胆管癌根治术的应用现状、优势及局限性.中华腔镜外科杂志（电子版）.2022;15(2):69-72.蔡建鹏，陈伟，王曦域，陈流华，殷晓煜。机器人辅助胰十二指肠切除术在高龄患者的应用。中华腔镜外科杂志。2021；14（1）：10-14. （通讯作者）陈流华，黄锡泰，陈伟，赖佳明，梁力建，殷晓煜。全尾状叶切除在肝门部胆管癌根治术中的应用。中华肝脏外科手术学杂志。2021；10（6）：559-563。（通讯作者）黄锡泰、蔡建鹏、陈伟、房鹏，陈流华，殷晓煜。机器人辅助保留脾脏远端胰腺切除术围手术期指标回顾性研究。中国实用外科杂志。2021；41（12）:1407-1422. （通讯作者）黄晨松，钟记华，陈伟，蔡建鹏，赖佳明，梁力建，殷晓煜。不同类型胰腺囊性肿瘤的诊断与治疗。中华消化外科杂志。2020；19（12）：1-7. （通讯作者）殷晓煜。机器人辅助下肝门部胆管癌III B型根治术。消化肿瘤杂志（电子版）。2020；12（4）:296-298.蔡建鹏，陈伟，陈流华，李仕进，殷晓煜。达芬奇机器人在胆总管囊肿手术切除中的应用。中华普通外科文献杂志（电子版）。2019；13（3）：194-7. （通讯作者）蔡建鹏，陈伟，陈流华，黄锡泰，李仕进，殷晓煜。机器人辅助肝切除术：附71例报告。中华肝脏外科手术学电子杂志。2019；8（3）：217-220. （通讯作者）殷晓煜。肝门部胆管癌术前行胆道引流术减轻黄疸的争议与策略。中华消化外科杂志。2018；17（3）：229-232. （通讯作者）五、专著：Yin XY. Diagnosis. In: Lau WY (ed). Hilar cholangiocarcinoma. Springer Science Business Media Dordrecht & People’s Medical Publishing House. 2013:91-98.