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张志新基因检测

张志新专家、博士生导师

四川大学华西第二医院西部妇幼医学研究院

1. 学历:博士,2. Email: Jason_Zhang2011@hotmail.com,3. 研究方向:B淋巴细胞发育和抗体产生的分子调控,细胞核骨架和B淋巴细胞基因表达以及免疫球蛋白基因重组,自身免疫疾病中,诸如红斑狼疮和风湿性关节炎,B淋巴细胞的异常功能,B淋巴细胞抗病毒反应,B淋巴瘤和白血病的发病机理,抗肿瘤抗体,免疫细胞治疗,4. 教育经历,1985-1989 学士/B.S. 南开大学,1989-1992 硕士/ M.S. 南开大学,1993-1997 博士/ Ph.D. 美国阿拉巴马大学伯明翰分校,1997-2003 博士后 美国阿拉巴马大学伯明翰分校,Max Cooper实验室,5.工作经历,2015- 四川大学华西第二医院,教授,免疫发育和疾病治疗实验室PI,2013- 终身教授,美国内布拉斯加大学医学中心病理和微生物系,2011-2013 终身副教授,美国内布拉斯加大学医学中心病理和微生物系,2008-2011 副教授,美国内布拉斯加大学医学中心病理和微生物系,2003-2008 助理教授,美国阿拉巴马大学伯明翰分校,6. 代表性论文:(1) Rogosch,T,KerzelS,Dey F,Wagner,J-J,Zhang Z,Maier RF,and Zemlin M. IgG4 and IgE transcripts in childhood allergic asthmareflect divergent antigen-driven selection. JImmunol,193:5801-5808,2014.,(2)Lange MD,Huang L,Yu Y,Li S,Liao H,Zemlin M,Su K,and Zhang Z*. Accumulation of VHReplacement Products in IgH Genes Derived from Autoimmune Diseases andAnti-Viral Responses in Human,FrontImmunol. 5:345,2014.,(3) Zhang B,Liang J,Zhang Z*,Role of biomarkers in management of complications after cardiac surgery. J Cardiovasc Surg (Torino). 55:1-2,2014.,(4)Huang L,Lange MD,and Zhang Z*. VH replacement footprintanalyser-I (VHRFA-I),a Java based computer program for analyses ofimmunoglobulin heavy chain genes and potential VH replacementproducts in human and mouse. Front.Immunol. 5:40,2014.,(5) Shi G,Zhang J,Zhang Z,Zhang X,Systemic autoimmunediseases. Clin Dev Immunol,2013:728574,2013,(6)Li S,Yu Y,Yue Y,Zhang Z,Su K,Microbial infection and rheumatoid arthritis. J Clin Cell Immunol,4:174,2013.,(7) Li S,Yu Y,Koehn CD,Zhang Z,Su K,Galectins in the Pathogenesis of Rheumatoid Arthritis. J Clin Cell Immunol,4:164,2013.,(8)Liu J,Xie W,Lange M,Hong SY,SuK,and Zhang Z*,Internalization of B cell receptors (BCRs) in human EU12 muHC+immature B cells specifically alters downstream signaling events. BioMed Res International,2013:807240,2013.,(9)Huang X,Huang L,Peng H,Guru A,Xue W,Hong SY,Liu M,Sharma S,Fu K,Caprez AP,Swanson DR,Zhang Z,and Ding S-H,ISPTM: An iterative search algorithm for systematicidentification of post-translational modifications from complex proteomemixtures. J Proteome Res,12:3831−3842,2013.,(10)Liu J,Lange M,Hong SY,Xie W,Huang L,Ehrhardt G,Burrows PD,Su K,Carter R,and Zhang Z*,Regulation of VH replacement by B cell receptor (BCR)-mediatedsignaling in human immature B cells. J.Immunol. 190:5559-5566,2013.,(11)Huang L,Lange MD,Yu Y,LiS,Su K,and Zhang Z*. Contributionof VH replacement products in mouse antibody repertoire. PLoSOne,8:e57877,2013.,(12)Liao H,Run F,LiuJ,Lange M,Su K,and Zhang Z*,Contribution of VH replacement products to the generation ofanti-HIV antibodies. Clinical Immunol,146:46-55,2013.,(13) He T,Hong SY,Huang L,Xue W,Yu Z,Kwon H,Kirk M,Ding SJ,Su K,Zhang Z*.Histoneacetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediatedtranscriptional activity. J Biol Chem.286:14137-14145. 2011.
张志新 —— 专家简介
1. 学历:博士,2. Email: Jason_Zhang2011@hotmail.com,3. 研究方向:B淋巴细胞发育和抗体产生的分子调控,细胞核骨架和B淋巴细胞基因表达以及免疫球蛋白基因重组,自身免疫疾病中,诸如红斑狼疮和风湿性关节炎,B淋巴细胞的异常功能,B淋巴细胞抗病毒反应,B淋巴瘤和白血病的发病机理,抗肿瘤抗体,免疫细胞治疗,4. 教育经历,1985-1989 学士/B.S. 南开大学,1989-1992 硕士/ M.S. 南开大学,1993-1997 博士/ Ph.D. 美国阿拉巴马大学伯明翰分校,1997-2003 博士后 美国阿拉巴马大学伯明翰分校,Max Cooper实验室,5.工作经历,2015- 四川大学华西第二医院,教授,免疫发育和疾病治疗实验室PI,2013- 终身教授,美国内布拉斯加大学医学中心病理和微生物系,2011-2013 终身副教授,美国内布拉斯加大学医学中心病理和微生物系,2008-2011 副教授,美国内布拉斯加大学医学中心病理和微生物系,2003-2008 助理教授,美国阿拉巴马大学伯明翰分校,6. 代表性论文:(1) Rogosch,T,KerzelS,Dey F,Wagner,J-J,Zhang Z,Maier RF,and Zemlin M. IgG4 and IgE transcripts in childhood allergic asthmareflect divergent antigen-driven selection. JImmunol,193:5801-5808,2014.,(2)Lange MD,Huang L,Yu Y,Li S,Liao H,Zemlin M,Su K,and Zhang Z*. Accumulation of VHReplacement Products in IgH Genes Derived from Autoimmune Diseases andAnti-Viral Responses in Human,FrontImmunol. 5:345,2014.,(3) Zhang B,Liang J,Zhang Z*,Role of biomarkers in management of complications after cardiac surgery. J Cardiovasc Surg (Torino). 55:1-2,2014.,(4)Huang L,Lange MD,and Zhang Z*. VH replacement footprintanalyser-I (VHRFA-I),a Java based computer program for analyses ofimmunoglobulin heavy chain genes and potential VH replacementproducts in human and mouse. Front.Immunol. 5:40,2014.,(5) Shi G,Zhang J,Zhang Z,Zhang X,Systemic autoimmunediseases. Clin Dev Immunol,2013:728574,2013,(6)Li S,Yu Y,Yue Y,Zhang Z,Su K,Microbial infection and rheumatoid arthritis. J Clin Cell Immunol,4:174,2013.,(7) Li S,Yu Y,Koehn CD,Zhang Z,Su K,Galectins in the Pathogenesis of Rheumatoid Arthritis. J Clin Cell Immunol,4:164,2013.,(8)Liu J,Xie W,Lange M,Hong SY,SuK,and Zhang Z*,Internalization of B cell receptors (BCRs) in human EU12 muHC+immature B cells specifically alters downstream signaling events. BioMed Res International,2013:807240,2013.,(9)Huang X,Huang L,Peng H,Guru A,Xue W,Hong SY,Liu M,Sharma S,Fu K,Caprez AP,Swanson DR,Zhang Z,and Ding S-H,ISPTM: An iterative search algorithm for systematicidentification of post-translational modifications from complex proteomemixtures. J Proteome Res,12:3831−3842,2013.,(10)Liu J,Lange M,Hong SY,Xie W,Huang L,Ehrhardt G,Burrows PD,Su K,Carter R,and Zhang Z*,Regulation of VH replacement by B cell receptor (BCR)-mediatedsignaling in human immature B cells. J.Immunol. 190:5559-5566,2013.,(11)Huang L,Lange MD,Yu Y,LiS,Su K,and Zhang Z*. Contributionof VH replacement products in mouse antibody repertoire. PLoSOne,8:e57877,2013.,(12)Liao H,Run F,LiuJ,Lange M,Su K,and Zhang Z*,Contribution of VH replacement products to the generation ofanti-HIV antibodies. Clinical Immunol,146:46-55,2013.,(13) He T,Hong SY,Huang L,Xue W,Yu Z,Kwon H,Kirk M,Ding SJ,Su K,Zhang Z*.Histoneacetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediatedtranscriptional activity. J Biol Chem.286:14137-14145. 2011.

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