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蒋琳加基因检测

蒋琳加研究员

中山大学孙逸仙纪念医院基础与转化医学研究中心

2017年中山大学“百人计划”引进人才。以第一作者及通讯作者在Nat. Cell Bio.,Blood,J. Hematol. Oncol.,Adv. Sci.,PNAS,Mol. Cell,eLife等高影响力杂志发表论文多篇,获得广东省杰出青年,主持国自然青年、面上项目,参与国家重点研发计划“干细胞及转化研究”专项及广东省重点领域研究计划等项目。研究方向:利用小鼠及斑马鱼模型研究微环境对正常造血干细胞自我更新和造血重建能力的调控作用和机制,以及白血病状态下造血微环境的改变对疾病的发生、发展和治疗的影响。联系方式:jianglj7@mail.sysu.edu.cn,发表论文:1.Yanhui Yu#,Yabin Meng#,Xi Xu#,Tong Tong#,Chong He,Liying Wang,Kaitao Wang,Minyi Zhao,Xinru You,Wenwen Zhang,Linjia Jiang*,Jun Wu*,Meng Zhao*. A Ferroptosis-inducing and luekmeic cell-targeting drub nanocarrier formed by redox-responsive cysteine polymer for acute myeloid leukemia therapy. ACS NANO (IF 18.027),2023/2/8,17(4):3334-3345,2.Xi Xu#,Wenwen Zhang#,Li Xuan#,Yanhui Yu,Wen Zheng,Fang Tao,Jacquelyn Nemechek,Chong He,Weiwei Ma,Xue Han,Siyu Xie,Minyi Zhao,Jian Wang,Yuhua Qu,Qifa Liu,John M. Perry,Linjia Jiang*,Meng Zhao*. PD-1 signalling defines and protects leukaemic stem cells from T cell receptor-induced cell death in T cell acute lymphoblastic leukaemia. Nature Cell Biology (IF 28.213),2023/1/9,25(1):170-182.,3.Qi Lou#,Kaizheng Jiang#,Quanhui Xu#,Lisha Yuan,Siyu Xie,Yuan Pan,Jian Chen,Jun Wu,Jiang Zhu,Linjia Jiang*,Meng Zhao*. The RIG-I-NRF2 axis regulates the mesenchymal stromal niche for bone marrow transplantation. Blood (IF 25.669),2022/5/26,139(21):3204-3221.,4.Changzheng Li#; Xinru You#; Xi Xu#; Binghuo Wu; Yuye Liu; Tong Tong; Jie Che; Yishan Li; Chunlei Dai; Zhitao Ye; Xiaobin Tian; Yan Wei; Zechen Hao; Linjia Jiang*; Jun Wu*; Meng Zhao*. A Metabolic Reprogramming Amino Acid Polymer as an Immunosurveillance Activator and Leukemia Targeting Drug Carrier for T-Cell Acute Lymphoblastic Leukemia. Advanced Science (IF 17.521),2022/01/26,9(9):2104134-2104148.,5.Xi Xu#,Jian Wang#,Tong Tong#,Wenwen Zhang,Jin Wang,Weiwei Ma,Shunqing Wang,Dunhua Zhou,Jun Wu*,Linjia Jiang* and Meng Zhao*. A self-assembled leucine polymer sensitizes leukemic stem cells to chemotherapy by inhibiting autophagy in acute myeloid leukemia. Haematologica (IF 11.047),2022/03/10,107(10):2344-2355.,6.Yunxin Zeng#,Xinyu Zhang#,Dongjun Lin#,Xiaohui Feng,Yuye Liu,Zhengwen Fang,Weijian Zhang,Yu Chen,Meng Zhao*,Jun Wu*,Linjia Jiang*. A lysosometargeted dextrandoxorubicin nanodrug overcomes doxorubicin-induced chemoresistance of myeloid leukemia. Journal of Hematology and Oncology (IF 23.168),2021/11/8 14 (1):189.,7.Zhian Ye#,Zhongwu Su#,Siyu Xie,Yuye Liu,Yongqiang Wang,Xi Xu,Yiqing Zheng*,Meng Zhao*,Linjia Jiang*. Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration. Elife (IF 8.713,Nature Index期刊),2020/4/30 9:e55771.,8.Linjia Jiang#,Xue Han#,Jin Wang#,Chen Wang,Xiaoqiang Sun,Jiayi Xie,Guojin Wu,Hiep Phan,Zhenguo Liu,Chengcheng Zhang*,Meng Zhao*,Xunlei Kang*. SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-β signaling. Journal of Experimental Medicine (IF 10.892),2018/4/18 215(5):1337-1347,9.Jiang L,Romero-Carvajal A,Haug JS,Seidel CW,Piotrowski T*. Gene-expression analysis of hair cell regeneration in the zebrafish lateral line. PNAS (IF 9.661,highlighted by F1000) 2014; 111 (14): E1383-92.,10.Li XY#,Jiang LJ#,Chen L,Ding ML,Guo HZ,Zhang W,Zhang HX,Ma XD,Liu XZ,Xi XD,Chen SJ,Chen Z,Zhu J*. RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness. Molecular Cell (IF 14.714) 2014; 53(3):407-19.,11.Xi Xu#,Yanhui Yu#,Wenwen Zhang#,Weiwei Ma#,Chong He#,Guo Qiu,Xinyi Wang,Qiong Liu,Minyi Zhao,Jiayi Xie,Fang Tao,John M. Perry,Qifa Liu,Shuan Rao,* Xunlei Kang,* Meng Zhao*,Linjia Jiang*. SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming. Nature Cell Biology,2024/2/6,26:464-477.,主持或参加的科研项目:1、国家重点研发计划,干细胞研究与器官修复专项,2022YFA1103302,“重大血液疾病及其治疗相关造血干细胞损伤修复调控机制研究”,2022/12-2027/11,100万/2795万,8/16。2、国家自然科学基金委员会,重大研究计划,92268205,“单细胞多维组学解码造血干细胞损伤修复调控机制”,2023/1-2026/12,100万/300万,2/6。3、广东省科技厅,杰出青年项目,2021B1515020012,“成体干细胞自我更新的调控机制”,2021/1-2024/12,100万元,在研,主持。4、中山大学高校基本业务费,青年教师培育项目,19ykpy98,“TGFβ-SHP1通路调控白血病干细胞的功能和机制研究”,2019/01-2021/12,15万,主持。5、广东省科技厅,重点领域研发计划,2019B020234002,“造血干细胞的谱系层级、微环境调控及制备策略”,2019/1-2021/12,50万/300万,在研,参与,6、国家自然科学基金委员会,面上项目,31871467,“yap/taz-lin28a通路促进听觉毛细胞再生修复的功能和机制研究”,2019/1-2022/12,59万元,主持。7、国家自然科学基金委员会,青年项目,81800164,“非编码RNA H19通过cohesin复合体调控白血病发病的功能和机制研究”,2019/1-2021/12,21万元,主持。
蒋琳加 —— 专家简介
2017年中山大学“百人计划”引进人才。以第一作者及通讯作者在Nat. Cell Bio.,Blood,J. Hematol. Oncol.,Adv. Sci.,PNAS,Mol. Cell,eLife等高影响力杂志发表论文多篇,获得广东省杰出青年,主持国自然青年、面上项目,参与国家重点研发计划“干细胞及转化研究”专项及广东省重点领域研究计划等项目。研究方向:利用小鼠及斑马鱼模型研究微环境对正常造血干细胞自我更新和造血重建能力的调控作用和机制,以及白血病状态下造血微环境的改变对疾病的发生、发展和治疗的影响。联系方式:jianglj7@mail.sysu.edu.cn,发表论文:1.Yanhui Yu#,Yabin Meng#,Xi Xu#,Tong Tong#,Chong He,Liying Wang,Kaitao Wang,Minyi Zhao,Xinru You,Wenwen Zhang,Linjia Jiang*,Jun Wu*,Meng Zhao*. A Ferroptosis-inducing and luekmeic cell-targeting drub nanocarrier formed by redox-responsive cysteine polymer for acute myeloid leukemia therapy. ACS NANO (IF 18.027),2023/2/8,17(4):3334-3345,2.Xi Xu#,Wenwen Zhang#,Li Xuan#,Yanhui Yu,Wen Zheng,Fang Tao,Jacquelyn Nemechek,Chong He,Weiwei Ma,Xue Han,Siyu Xie,Minyi Zhao,Jian Wang,Yuhua Qu,Qifa Liu,John M. Perry,Linjia Jiang*,Meng Zhao*. PD-1 signalling defines and protects leukaemic stem cells from T cell receptor-induced cell death in T cell acute lymphoblastic leukaemia. Nature Cell Biology (IF 28.213),2023/1/9,25(1):170-182.,3.Qi Lou#,Kaizheng Jiang#,Quanhui Xu#,Lisha Yuan,Siyu Xie,Yuan Pan,Jian Chen,Jun Wu,Jiang Zhu,Linjia Jiang*,Meng Zhao*. The RIG-I-NRF2 axis regulates the mesenchymal stromal niche for bone marrow transplantation. Blood (IF 25.669),2022/5/26,139(21):3204-3221.,4.Changzheng Li#; Xinru You#; Xi Xu#; Binghuo Wu; Yuye Liu; Tong Tong; Jie Che; Yishan Li; Chunlei Dai; Zhitao Ye; Xiaobin Tian; Yan Wei; Zechen Hao; Linjia Jiang*; Jun Wu*; Meng Zhao*. A Metabolic Reprogramming Amino Acid Polymer as an Immunosurveillance Activator and Leukemia Targeting Drug Carrier for T-Cell Acute Lymphoblastic Leukemia. Advanced Science (IF 17.521),2022/01/26,9(9):2104134-2104148.,5.Xi Xu#,Jian Wang#,Tong Tong#,Wenwen Zhang,Jin Wang,Weiwei Ma,Shunqing Wang,Dunhua Zhou,Jun Wu*,Linjia Jiang* and Meng Zhao*. A self-assembled leucine polymer sensitizes leukemic stem cells to chemotherapy by inhibiting autophagy in acute myeloid leukemia. Haematologica (IF 11.047),2022/03/10,107(10):2344-2355.,6.Yunxin Zeng#,Xinyu Zhang#,Dongjun Lin#,Xiaohui Feng,Yuye Liu,Zhengwen Fang,Weijian Zhang,Yu Chen,Meng Zhao*,Jun Wu*,Linjia Jiang*. A lysosometargeted dextrandoxorubicin nanodrug overcomes doxorubicin-induced chemoresistance of myeloid leukemia. Journal of Hematology and Oncology (IF 23.168),2021/11/8 14 (1):189.,7.Zhian Ye#,Zhongwu Su#,Siyu Xie,Yuye Liu,Yongqiang Wang,Xi Xu,Yiqing Zheng*,Meng Zhao*,Linjia Jiang*. Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration. Elife (IF 8.713,Nature Index期刊),2020/4/30 9:e55771.,8.Linjia Jiang#,Xue Han#,Jin Wang#,Chen Wang,Xiaoqiang Sun,Jiayi Xie,Guojin Wu,Hiep Phan,Zhenguo Liu,Chengcheng Zhang*,Meng Zhao*,Xunlei Kang*. SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-β signaling. Journal of Experimental Medicine (IF 10.892),2018/4/18 215(5):1337-1347,9.Jiang L,Romero-Carvajal A,Haug JS,Seidel CW,Piotrowski T*. Gene-expression analysis of hair cell regeneration in the zebrafish lateral line. PNAS (IF 9.661,highlighted by F1000) 2014; 111 (14): E1383-92.,10.Li XY#,Jiang LJ#,Chen L,Ding ML,Guo HZ,Zhang W,Zhang HX,Ma XD,Liu XZ,Xi XD,Chen SJ,Chen Z,Zhu J*. RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness. Molecular Cell (IF 14.714) 2014; 53(3):407-19.,11.Xi Xu#,Yanhui Yu#,Wenwen Zhang#,Weiwei Ma#,Chong He#,Guo Qiu,Xinyi Wang,Qiong Liu,Minyi Zhao,Jiayi Xie,Fang Tao,John M. Perry,Qifa Liu,Shuan Rao,* Xunlei Kang,* Meng Zhao*,Linjia Jiang*. SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming. Nature Cell Biology,2024/2/6,26:464-477.,主持或参加的科研项目:1、国家重点研发计划,干细胞研究与器官修复专项,2022YFA1103302,“重大血液疾病及其治疗相关造血干细胞损伤修复调控机制研究”,2022/12-2027/11,100万/2795万,8/16。2、国家自然科学基金委员会,重大研究计划,92268205,“单细胞多维组学解码造血干细胞损伤修复调控机制”,2023/1-2026/12,100万/300万,2/6。3、广东省科技厅,杰出青年项目,2021B1515020012,“成体干细胞自我更新的调控机制”,2021/1-2024/12,100万元,在研,主持。4、中山大学高校基本业务费,青年教师培育项目,19ykpy98,“TGFβ-SHP1通路调控白血病干细胞的功能和机制研究”,2019/01-2021/12,15万,主持。5、广东省科技厅,重点领域研发计划,2019B020234002,“造血干细胞的谱系层级、微环境调控及制备策略”,2019/1-2021/12,50万/300万,在研,参与,6、国家自然科学基金委员会,面上项目,31871467,“yap/taz-lin28a通路促进听觉毛细胞再生修复的功能和机制研究”,2019/1-2022/12,59万元,主持。7、国家自然科学基金委员会,青年项目,81800164,“非编码RNA H19通过cohesin复合体调控白血病发病的功能和机制研究”,2019/1-2021/12,21万元,主持。

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