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罗曼莉基因检测

罗曼莉研究员

中山大学孙逸仙纪念医院基础与转化医学研究中心

研究方向:肿瘤细胞可塑性调控新机制和治疗靶点研究,联系方式:luomli@mail.sysu.edu.cn,罗曼莉,中山大学孙逸仙纪念医院研究员,博士生导师,医学研究中心副主任。博士毕业于北京协和医科大学中国医学科学院,2015年在哈佛医学院完成博士后工作,以中山大学百人计划引进回国。主要从事肿瘤细胞可塑性调控的新机制和潜在治疗靶点研究。承担国家自然科学基金项目和科技部国家重点研发计划课题。近五年在Nat Commun,EMBO J,J Natl Cancer Inst,Cancer Res等著名学术期刊发表论文多篇,获评“广东特支计划”科技创新人才。近年发表论文(时间倒序排列,#为第一作者,*为通讯作者):Guo Q#,Li Y#,Zhang Y#,Shen L,Lin H,Chen J,Song E*,Luo ML*. LncRNA NRON promotes tumorigenesis by enhancing MDM2 activity toward tumor suppressor substrates. EMBO J. 2023;42:e112414. (IF 11.4),Wu L#,Bai S#,Huang J#,Cui G,Li Q,Wang J,Du X,Fu W,Li C,Wei W,Lin H*,Luo ML*. Nigericin Boosts Anti-Tumor Immune Response via Inducing Pyroptosis in Triple-Negative Breast Cancer. Cancers. 2023;15:3221. (IF 5.2),Chen X#,Luo R#,Zhang Y#,Ye S,Zeng X,Liu J,Huang D,Liu Y,Liu Q,Luo ML*,Song E*. Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer. Nat Commun. 2022;13:7160. (IF 16.6),Tan J#,Zhou SN#,Zhang W#,Yang B,Zhong GY,Huang J,Hu H,Han FH*,Luo ML*. Long noncoding RNA OVAAL enhances nucleotide synthesis through pyruvate carboxylase to promote 5-fluorouracil resistance in gastric cancer. Cancer Sci. 2022;113:3055-3070. (IF 5.7),Luo ML#,Zheng F#,Chen W,Liang ZM,Chandramouly G,Tan J,Willis N,Chen CH,Taveira MO,Zhou XZ,Lu KP,Scully R,Wulf GM*,Hu H*. Inactivation of the prolyl isomerase Pin1 sensitizes BRCA1-proficient breast cancer to PARP inhibition. Cancer Res. 2020;80:3033-3045. (IF 11.2),Luo ML#,Li J#,Shen L#,Chu J#,Guo Q,Liang G,Wu W,Chen J,Chen R,Song E*. The Role of APAL/ST8SIA6-AS1 lncRNA in PLK1 Activation and Mitotic Catastrophe of Tumor Cells. J Natl Cancer Inst. 2020;112: 356-368. (IF 10.3),Huang S#,Chen Y#,Liang ZM,Li NN,Liu Y,Zhu Y,Liao D,Zhou XZ,Lu KP,Yao Y*,Luo ML*. Targeting Pin1 by All-Trans Retinoic Acid (ATRA) Overcomes Tamoxifen Resistance in Breast Cancer via Multifactorial Mechanisms. Front Cell Dev Biol. 2019;7:322. (IF 5.5),Wang P#,Luo ML#,Song E,Zhou Z,Ma T,Wang J,Jia N,Wang G,Nie S,Liu Y,Hou F*. Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway. Sci Transl Med. 2018;10:eaat2039. (IF 17.1),Luo ML#,Zhou Z#,Sun L,Yu L,Sun L,Liu J,Yang Z,Ran Y,Yao Y*,Hu H*. An ADAM12 and FAK positive feedback loop amplifies the interaction signal of tumor cells with extracellular matrix to promote esophageal cancer metastasis. Cancer Lett. 2018;422:118-128. (IF 9.7)
罗曼莉 —— 专家简介
研究方向:肿瘤细胞可塑性调控新机制和治疗靶点研究,联系方式:luomli@mail.sysu.edu.cn,罗曼莉,中山大学孙逸仙纪念医院研究员,博士生导师,医学研究中心副主任。博士毕业于北京协和医科大学中国医学科学院,2015年在哈佛医学院完成博士后工作,以中山大学百人计划引进回国。主要从事肿瘤细胞可塑性调控的新机制和潜在治疗靶点研究。承担国家自然科学基金项目和科技部国家重点研发计划课题。近五年在Nat Commun,EMBO J,J Natl Cancer Inst,Cancer Res等著名学术期刊发表论文多篇,获评“广东特支计划”科技创新人才。近年发表论文(时间倒序排列,#为第一作者,*为通讯作者):Guo Q#,Li Y#,Zhang Y#,Shen L,Lin H,Chen J,Song E*,Luo ML*. LncRNA NRON promotes tumorigenesis by enhancing MDM2 activity toward tumor suppressor substrates. EMBO J. 2023;42:e112414. (IF 11.4),Wu L#,Bai S#,Huang J#,Cui G,Li Q,Wang J,Du X,Fu W,Li C,Wei W,Lin H*,Luo ML*. Nigericin Boosts Anti-Tumor Immune Response via Inducing Pyroptosis in Triple-Negative Breast Cancer. Cancers. 2023;15:3221. (IF 5.2),Chen X#,Luo R#,Zhang Y#,Ye S,Zeng X,Liu J,Huang D,Liu Y,Liu Q,Luo ML*,Song E*. Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer. Nat Commun. 2022;13:7160. (IF 16.6),Tan J#,Zhou SN#,Zhang W#,Yang B,Zhong GY,Huang J,Hu H,Han FH*,Luo ML*. Long noncoding RNA OVAAL enhances nucleotide synthesis through pyruvate carboxylase to promote 5-fluorouracil resistance in gastric cancer. Cancer Sci. 2022;113:3055-3070. (IF 5.7),Luo ML#,Zheng F#,Chen W,Liang ZM,Chandramouly G,Tan J,Willis N,Chen CH,Taveira MO,Zhou XZ,Lu KP,Scully R,Wulf GM*,Hu H*. Inactivation of the prolyl isomerase Pin1 sensitizes BRCA1-proficient breast cancer to PARP inhibition. Cancer Res. 2020;80:3033-3045. (IF 11.2),Luo ML#,Li J#,Shen L#,Chu J#,Guo Q,Liang G,Wu W,Chen J,Chen R,Song E*. The Role of APAL/ST8SIA6-AS1 lncRNA in PLK1 Activation and Mitotic Catastrophe of Tumor Cells. J Natl Cancer Inst. 2020;112: 356-368. (IF 10.3),Huang S#,Chen Y#,Liang ZM,Li NN,Liu Y,Zhu Y,Liao D,Zhou XZ,Lu KP,Yao Y*,Luo ML*. Targeting Pin1 by All-Trans Retinoic Acid (ATRA) Overcomes Tamoxifen Resistance in Breast Cancer via Multifactorial Mechanisms. Front Cell Dev Biol. 2019;7:322. (IF 5.5),Wang P#,Luo ML#,Song E,Zhou Z,Ma T,Wang J,Jia N,Wang G,Nie S,Liu Y,Hou F*. Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway. Sci Transl Med. 2018;10:eaat2039. (IF 17.1),Luo ML#,Zhou Z#,Sun L,Yu L,Sun L,Liu J,Yang Z,Ran Y,Yao Y*,Hu H*. An ADAM12 and FAK positive feedback loop amplifies the interaction signal of tumor cells with extracellular matrix to promote esophageal cancer metastasis. Cancer Lett. 2018;422:118-128. (IF 9.7)

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