研究员，导师资格：博士生导师，招生专业：分子医学，联系方式：yind3@mail.sysu.edu.cn，一、简介：遗传物质变异的积累是肿瘤发生发展的重要原因之一。多年来，围绕肿瘤的遗传和表观遗传学展开深入研究。包括肿瘤的基因突变和表达、核酸和组蛋白修饰、染色质重塑、DNA损伤修复等。发现多个肿瘤相关基因的遗传和表观遗传改变，揭示细胞周期调控异常与肿瘤发生发展，以及DNA损伤修复与肿瘤耐药的机制。发表论文近百篇，总引用6900多次，H指数45（来自Google Scholar），其中以第一/通讯作者（含共同）在Nature、Advance Science、Cancer Research、Nucleic Acids Research、Clinical Cancer Research、Oncogene等杂志发表SCI研究论文60余篇。二、主要研究方向，1. 肿瘤基因组学和肿瘤分子遗传学；2. 肿瘤基因表观调控；3. 肿瘤DNA损伤修复与耐药机制；4. 肿瘤分子分型与分子诊断。三、代表论著 (#第一作者，*通讯作者)，Chen H#，Li Y#，Li H#，Chen X，Fu H，Mao D，Chen W，Lan L，Wang C，Hu K，Li J，Zhu C，Evans I，Cheung E，Lu D，He Y*，Behrens A*，Yin Dong*，Zhang C*. NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance. Nature. 2024 Jul 3. doi: 10.1038/s41586-024-07620-9，Li W，Han Q，Zhu Y，Zhou Y，Zhang J，Wu W，Li Y，Liu L，Qiu Y，Hu K*，Yin Dong*. SUMOylation of RNF146 results in Axin degradation and activation of Wnt/β-catenin signaling to promote the progression of hepatocellular carcinoma. Oncogene. 2023 May;42(21):1728-1740，Li Y，Chen H，Xie X，Yang B，Wang X，Zhang J，Qiao T，Guan J，Qiu Y，Huang YX，Tian D，Yao X，Lu D，Koeffler HP，Zhang Y*，Yin Dong*. PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells. Cancer Research. 2023 Feb 3;83(3):398-413，Yongsheng Huang#，Qian Yang#，Yueyuan Zheng#，Lehang Lin#，Xin Xu，Xiu-E Xu，Tiago C Silva，Masaharu Hazawa，Li Peng，Haotian Cao，Yanbing Ding，Daning Lu，Benjamin P Berman，Li-Yan Xu*，En-Min Li*，Yin Dong*. Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma. Nucleic Acids Research. 2021 Aug 9;gkab679.，Kaishun Hu#，Yu Li#，Wenjing Wu#，Limin Xie#，Haiyan Yan，Yuexin Cai，Dong Chen，Qiongchao Jiang，Lehang Lin，Zhen Chen，Jian-You Liao，Yin Zhang，H. Phillip Koeffler，Yin Dong* and Erwei Song*. ATM-dependent recruitment of BRD7 is required for transcriptional repression and DNA repair at DNA breaks flanking transcriptional active regions. Advanced Science 2020.7，2000157，Hengxing Chen#，Yun Li1#，Yu Li1，Zhen Chen，Limin Xie，Wenjia Li，Yuanxin Zhu，Hong Xue，H. Phillip Koeffler，Wenjing Wu，Kaishun Hu*，Yin Dong*. PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2. Theranostics. 2020; 10(22): 9984–10000，He J#，Huang Z#，He M，Liao J，Zhang Q，Wang S，Xie L，Ouyang L，Koeffler HP，Yin Dong*，Liu A*. Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas. Mol Cancer. 2020;19(1):17，Hu K#，Wu W#，Li Y#，Lin L，Chen D，Yan H，Xiao X，Chen H，Chen Z，Zhang Y，Xu S，Guo Y，Koeffler HP，Song E*，Yin Dong*. Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.. 2019 May;20(5). PubMed PMID: 30940648; EMBO Report.，Lehang Lin#，Moli Huang#，Xianping Shi#，Anand Mayakonda，Kaishun Hu，Yan-Yi Jiang，Xiao Guo，Li Chen，Brendan Pang，Ngan Doan，Jonathan W. Said，Jianjun Xie，Sigal Gery，Xu Cheng，Zhaoyu Lin，Jinsong Li，Benjamin P. Berman，Yin Dong*，De-Chen Lin*，H. Phillip Koeffler. Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1. 2018. Nucleic Acids Research.，De-Chen Lin#*，Anand Mayakonda，Huy Q Dinh，Pinbo Huang，Lehang Lin，Xiaoping Liu，Ling-Wen Ding，jie wang，Benjamin Berman，Erwei Song，Yin Dong* and H. Phillip Koeffler. Genomic and epigenomic heterogeneity of hepatocellular carcinoma. 2017. Cancer Research.，De-Chen Lin#*，Liang Xu，Ye Chen，Haiyan Yan，Masaharu Hazawa，Ngan Doan，Jonathan W. Said，Ling-Wen Ding，Li-Zhen Liu，Henry Yang，Shizhu Yu，Michael Kahn，Yin Dong*，H. Phillip Koeffler. Genomic and functional analysis of the E3 ligase PARK2 in glioma. 2015，75(9):1815-27. Cancer Research.，Yin Dong#*，Seishi Ogawa，Norihiko Kawamata，Amanda Leiter，Michelle Ham，Dong Li，Ngan B Doan，Jonathan W. Said，Keith L. Black，H. Phillip Koeffler (2013). miR-34a functions as a tumor suppressor modulating EGFR in glioblastoma multiforme. 2013 Feb 28;32(9):1155-63. Oncogene.，Yin Dong#*，Chen W，O'Kelly J，Lu D，Ham M，Doan NB，Xie D，Wang C，Vadgama J，Said，JW，Black KL，Koeffler HP. Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme. 2010. 127(10):2257-67. International Journal of Cancer，Yin Dong#*，Naoki Wakimoto，Hongtao Xing，Daning Lu，Thien Huynh，Xiao Wang，Keith L. Black，H. Phillip Koeffler (2008). Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme. 15;123(6):1364-75. International Journal of Cancer.，Yin Dong#*，John M. Ong，Jinwei Hu，Julian C. Desmond，Norihiko Kawamata，Bindu M Konda，Keith L. Black，H. Phillip Koeffler. （2007）SuberoylanilideHydroxamic Acid (SAHA)，a Histone Deacetylase Inhibitor: Effects on Gene Expression and Growth of Glioma Cells in vitro and vivo. 13(3):1045-1052. Clinical Cancer Research.，Yin Dong#*，Dong Xie，Sakura Sakajiri，Carl W. Miller，Hui Zhu，Miriam L. Popoviciu，Johathan W. Said，Keith L Black，and H. Phillip Koeffler. (2006) DLK1: Increased expression in gliomas and associated with oncogenic activities. 25:1852-1861. Oncogene，Yin Dong#*，Hong Zhou，Kumagai Takashi，Gentao Liu，John M. Ong2 Keith L. Black，and H. Phillip Koeffler. (2005) Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastomamultiforme (GBM). 24: 344–354. Oncogene.，Yin Dong#*，Dong Xie，Wolf-Karsten Hofmann，Carl W. Miller，Keith L Black，H. Phillip Koeffler. (2002) Methylation，Expression，and Mutation Analysis of the Cell Cycle Control Genes in Human Brain Tumors. 21:8372-8378. Oncogene.